Evansville is a city in and the county seat of Vanderburgh County, Indiana, United States. The population was 118,414 at the 2020 census, making it the state's third-most populous city after Indianapolis and Fort Wayne, the largest city in Southern Indiana, and the 249th-most populous city in the United States. It is the central city of the Evansville metropolitan area, a hub of commercial, medical, and cultural activity of southwestern Indiana and the Illinois–Indiana–Kentucky tri-state area, that is home to over 911,000 people. The 38th parallel crosses the north side of the city and is marked on Interstate 69.

Situated on an oxbow in the Ohio River, the city is often referred to as the "Crescent Valley" or "River City". Early French explorers named it La Belle Rivière ("The Beautiful River"). The area has been inhabited by various indigenous cultures for millennia, dating back at least 10,000 years. Angel Mounds was a permanent settlement of the Mississippian culture from 1000 AD to around 1400 AD. The European-American city was founded in 1812.

Evansville anchors a regional economic hub based primarily on trade, transportation, and utilities; professional and business services; education and health services; government; leisure and hospitality; and manufacturing. Two NYSE-listed companies (Berry Global and OneMain Financial) are headquartered in Evansville, and three companies traded on NASDAQ (Escalade, Old National Bank, and Shoe Carnival) are also headquartered in Evansville.

Evansville is home to Bally's Evansville, the state's first casino; Mesker Park Zoo and Botanic Garden, one of the state's oldest and largest zoos; and sports tourism industry. The city has several notable educational institutions. The University of Evansville is a private school on the city's east side, while the University of Southern Indiana is a larger public institution just outside the city's westside limits. The Indiana University School of Medicine also maintains a campus in Evansville. Other local educational institutions include the nationally ranked Signature School, the Evansville Vanderburgh Public Library, and the Evansville Vanderburgh School Corporation.